Topbp1 cancer
Web5. apr 2024 · TopBP1 to be upregulated in breast cancer tissues. TopBP1 overexpression was associated with higher-grade tumors and reduced patient survival (Forma et al., 2012; Going et al., 2007; Liu et al., 2009). p53 is a well-studied tumor suppressor and in the majority of cancers, p53 is mutated leading to gain of function mutations in the http://www.cancerindex.org/geneweb/TOPBP1.htm
Topbp1 cancer
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WebExpression of TOPBP1 (Dpb11, KIAA0259, TOP2BP1) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. Web27. apr 2024 · Taken together, our study reveals the functional defects of cancer-associated TOPBP1 mutations in DDR and may provide new therapy targets for cancer treatment. TOPBP1 (Topoisomerase IIβ-binding protein 1) mediates protein–protein interaction and …
Web15. mar 2024 · Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy 29 June 2024 Yan Zhao, Xinping Huang, … TOPBP1 was first identified as a DNA damage protein through its association with BRCA1, which is a protein heavily implicated in breast cancer pathology. TOPBP1 was found in complex with BRCA1 at sites independent from replication forks (i.e identified by the DNA replication clamp proliferating cell nuclear antigen) during normal S phase. When DNA damage was induced at higher levels by γ irradiation, there was an increase in TOPBP1/BRCA1 at sites away from replicat…
Web28. apr 2012 · Aberrant expression of TopBP1 may lead to genomic instability and can have pathological consequences. In this study we aimed to investigate expression of TopBP1 … WebPatients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent. Read more. TOPBP1 is not prognostic in prostate cancer.
WebTopBP1 also acts as a transcriptional regulator, and we investigated how this activity influenced the HPV life cycle. We determined that TopBP1 levels are increased in cervical …
WebExpression of TOPBP1 (Dpb11, KIAA0259, TOP2BP1) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. robert half international inc minneapolis mnWeb1. máj 2024 · TopBP1 serves as a scaffold to assemble protein complexes in a phosphorylation-dependent manner via its multiple BRCT-repeats. Recently, it has become clear that TopBP1 is repurposed to scaffold different processes dependent on cell cycle regulated changes in phosphorylation of client proteins. robert half indianapolis jobsWebTOPBP1 PATHOLOGY CANCER ANTIBODIES AND VALIDATION Dictionary Human pathology PROGNOSTIC SUMMARYi Prognostic marker in liver cancer (unfavorable), endometrial cancer (unfavorable) and pancreatic cancer (unfavorable) robert half international benefitsWeb12. sep 2014 · The expression levels of TopBP1 and Claspin were increased in the cancer cells that survived radiation therapy. Depletion of TopBP1 or Claspin using shRNA showed an enhancement of sensitivity to radiation in radioresistant lung cancer cells (PC14PE6). Moreover, increased levels of TopBP1 or Claspin endowed cells a higher resistance to … robert half international competitorsWeb1. feb 2016 · Topoisomerase IIβ-binding protein 1 (TOPBP1) participates in DNA replication and DNA damage response; however, its role in DNA repair and relevance for human … robert half in portland meWeb27. okt 2024 · The topbp1 Mutant Seedlings Are Hypersensitive to DSB Induction by Cisplatin Cisplatin is a chemotherapy drug used in different types of cancer [ 19 ]. It produces DNA interstrand crosslinks that can stall replication forks during S phase and thus is very cytotoxic [ 20 ]. robert half incWeb15. jan 2024 · To investigate the physiological role of TopBP1, we have generated germ cell-specific TopBP1-depleted mouse model. TopBP1-deleted mice were infertile, showed a loss of germ cells and had meiotic defects. ... (2013M3A6A4045755) of the National Research Foundation, South Korea, and the National Cancer Center Grant (NCC-1710190, 1810042) … robert half international glassdoor