Myocredin
WebMar 1, 2024 · Targeting myocardin and MRTF-A by CCG-203971 leads to actin cytoskeleton-dependent inhibition of HSC activation, reduced cell contractility, impeded cell migration and proliferation, and decreased COL.1 expression in vitro and in vivo. Dual expression of myocardin and MRTF-A in HSCs may represent novel therapeutic targets in liver fibrosis. WebFeb 1, 2024 · Myocardin is a coactivator of SRF and plays a critical role in the development and differentiation of cardiac and smooth muscle cells. Myocardin can transcriptionally activate muscle-specific genes in a CArG-SRF-dependent way, and its expression represents a contractile and mature SMC phenotype.
Myocredin
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WebSmooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. WebMyocardin is expressed early in the morphogenetic program regulating cardiac development, and myocardin appears to play an important role in activating a set of SRF-regulated cardiac-specific proteins.3,37Expression of a dominant- negative myocardin mutant protein or exposure ofXenopus
WebMar 30, 2024 · The myocardin-mediated concerted up-regulation of JPH2 / CAV3 not only identifies a key adaptive mechanism of hibernation, but also has important implications in understanding and treating related heart diseases. Results LCC–RyR Intermolecular Signaling Efficiency Is Enhanced during Hibernation. WebMyocardin, a co-activator of SRF, is a master regulator of SM gene expression and can greatly increase SRF binding to the correct CArG box in the promoters of SM-specific …
WebNov 3, 2009 · Consistent with its role as a transcriptional coactivator, myocardin may regulate the adaptive response of the heart to growth factors and hemodynamic stress (9–12).Expression of dominant-negative myocardin-mutant protein blocks expression of genes encoding some cardiac-specific myofibrillar proteins and disrupts heart tube … WebSMYD2 Regulates Vascular Smooth Muscle Cell Phenotypic Switching and Intimal Hyperplasia via Interaction with Myocardin #preprints. 13 Apr 2024 17:05:25
WebFeb 27, 2024 · Myocardin and MRTF-A-induced actin cytoskeleton dynamics control their nuclear translocation. Since HSC activation is a central event in liver fibrogenesis , we first examined whether myocardin and MRTF-A are involved in HSC activation. In our well-established primary HSC culture model, robust actin cytoskeleton remodeling (reflected …
WebMar 6, 2024 · Myocardin is a transcriptional co-activator required for cardiovascular development, but also promotes cardiomyocyte survival through an unclear molecular … gloria saunders actress cause of deathWebJan 13, 2024 · Myocardin is a smooth and cardiac muscle-specific transcriptional coactivator of serum response factor. When expressed ectopically in nonmuscle cells, myocardin can induce smooth muscle differentiation by its association with serum response factor (SRF; 600589) ( Wang et al., 2001; Wang et al., 2003 ). Cloning and Expression boho california hotelsWebOct 25, 2024 · Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell. 2001; 105:851–862. doi: 10.1016/s0092-8674(01)00404-4 Crossref Medline Google Scholar; 12. Wang Z, Wang DZ, Pipes GC, Olson EN. Myocardin is a master regulator of smooth muscle gene expression. Proc Natl Acad … boho camper vans azWebFeb 1, 2024 · Myocardin (MYOCD) is a potent co-transcriptional activator of serum response factor (SRF) with the abilities to modulate the expression of SRF-target genes and … boho camper vans on shark tankWebMyocd regulates airway smooth muscle cell remodeling in response to chronic asthmatic injury. MYOCD is Required for Cardiomyocyte-like Cells Induction from Human Urine Cells and Fibroblasts Through Remodeling Chromatin. CARMN Is an Evolutionarily Conserved Smooth Muscle Cell-Specific LncRNA That Maintains Contractile Phenotype by Binding … gloria satterfield murdaugh housekeeperWebOct 23, 2002 · Myocardin is a SAP (SAF-A/B, Acinus, PIAS) domain transcription factor that associates with serum response factor (SRF) to potently enhance SRF-dependent … gloria saunders cause of deathWebThe myocardin gene was discovered using a bioinformatics-based screening strategy designed to identify novel cardiac-specific genes.3 Myocardin is a remarkably potent … boho canvas bag