Mitf phosphorylation
Web23 mrt. 2011 · The results showed that p-MITF was significantly elevated in the UV group compared with other groups (P < 0.05). We gather from this result that nitric oxide was …
Mitf phosphorylation
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Web23 jan. 2024 · MITF phosphorylation is short term and happens immediately after allergic trigger, since longer exposure time may lead to ubiquitin-mediated degradation, as was … Web1 aug. 2009 · In vitro, the activity of MITF is regulated by multiple signaling pathways, including the KITL/KIT/B-Raf pathway, which results in phosphorylation of MITF on …
Web31 mrt. 2011 · These findings are consistent with a phosphorylation event (supplemental Figure 4). However, the role of MITF phosphorylation in mediating KIT function in mast … Web9 nov. 2024 · Phosphorylation of p38 evokes Mitf expression, and the interaction between Mitf and NFATc1 is a prerequisite for the expression of TRAP, CTSK, and CTR [23,24,25]. Consequently, suppression of p38 by letrozole can downregulate the expression of TRAP, CTSK, CTR, and DC-STAMP [ 17 , 20 ].
Web24 aug. 2011 · Phosphorylation of Mitf increases its transcriptional activity and decreases the protein stability. The biological outcome of this interaction in cell culture models is to … Web26 aug. 2024 · Although the effects of MITF-Ser307 phosphorylation on activity in osteoclasts remain to be investigated further, it has been shown that the phosphorylated …
WebMITF AKT Phosphorylation TP53 Senescence a b s t r a c t Microphthalmia-associated transcription factor (MITF) plays a crucial role in the melanogenesis and proliferation of melanocytes that is dependent on its abundance and modification. Here, we report that epidermal growth factor (EGF) induces senescence and cyclin-dependent kinase ...
WebDownload scientific diagram Phosphorylation of MITF induced its degradation and change in cellular distribution. (A)SFB-MITF WT, S510D and S510A were transfected … find cnr numberWebAll lanes : Anti-MiTF (phospho S73) antibody (ab59201) at 1/500 dilution Lane 1 : COS-7 (African green monkey kidney fibroblast-like cell line) cell extract Lane 2 : COS-7 (African … find cnic on simWebUltraviolet (UV) radiation exposure is the primary cause of extrinsic skin aging, which results in skin hyperpigmentation and wrinkling. In this study, we investigated the whitening effect of (2E,5E)-2,5-bis(3-hydroxy-4-methoxybenzylidene)cyclopentanone (BHCP) on B16F10 melanoma and its anti-wrinkle activity on Hs27 fibroblasts cells. BHCP was found to … gtm medicalWeb23 mrt. 2024 · The switch was ERK dependent, and the expression of the melanoma-specific transcription factor and oncogene MITF (melanoma-associated transcription factor) was decreased. ... As PIK3CA-E545K increases S6K1 and S6 phosphorylation in the AKT/mTOR pathway, inhibition of the S6K1 kinase could be used to revert the resistance . gtm myisolved.com gtm myisolved.comWeb11 apr. 2024 · After blocking, the cytoslide was incubated with a primary antibody [Phospho-JNK (Cell Signaling, 9255 S) or Phospho-MITF (Millipore Sigma, SAB4503940)] in a buffer containing PBST and 0.1% BSA ... find cng stationsWeb3 okt. 2024 · ERK activation induces phosphorylation of MITF at serine 73, leading to its ubiquitination, followed by proteasome-mediated degradation. Moreover, sustained activation of ERK by C2 ceramide and sphingosine-1-phosphate (S1P) is reported to trigger MITF phosphorylation and subsequent degradation, resulting in reduced tyrosinase … gtm motorcycles 評判Web21 mrt. 2024 · MITF (Melanocyte Inducing Transcription Factor) is a Protein Coding gene. Diseases associated with MITF include Tietz Albinism-Deafness Syndrome and Melanoma, Cutaneous Malignant 8 . Among its … gtm music studios