WebSep 1, 2013 · BLyS, also known as B cell–activating factor, is a TNF ligand family cytokine that is produced by a variety of leukocytes, and provides essential, nonredundant signals necessary for B lymphocyte survival, … WebMay 13, 2009 · B lymphocyte stimulator (BLyS), a tumor necrosis factor family protein essential for B cell development, was previously shown to be expressed at an elevated …
Anti-Human BLys Recombinant Antibody (Belimumab)
B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B and CD257 among other names, is a protein that in humans is encoded by the TNFSF13B gene. BAFF is also known as B Lymphocyte Stimulator (BLyS) and TNF- and APOL-related leukocyte expressed ligand (TALL-1) and … See more BAFF is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFF-R. This cytokine is expressed in See more B-cell activating factor has been shown to interact with TNFRSF13B, TNFSF13, TNFRSF13C, and TNFRSF17. Interaction between BAFF and BAFF-R activates classical … See more As an immunostimulant, BAFF (BLyS, TALL-1) is necessary for maintaining normal immunity. Inadequate level of BAFF will fail to activate B cells to produce enough immunoglobulin and will lead to immunodeficiency. Excessive level of … See more Human BLyS has been expressed and purified in E. Coli. The BLyS protein in the engineered bacteria can be as much as 50% to the … See more • Nardelli B, Moore PA, Li Y, Hilbert DM (July 2002). "B lymphocyte stimulator (BLyS): a therapeutic trichotomy for the treatment of B lymphocyte diseases". Leukemia & … See more • B-Cell+Activating+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • Human DTL genome location and See more WebDec 15, 2015 · National Insitute of Immunology. Jul 1997 - Jun 20025 years. New Delhi, India. • Investigated the role of TNF family member, CD27 in … does amazon mouth swab
Belimumab - Wikipedia
WebB lymphocyte stimulator (BLyS), a soluble ligand of the TNF cytokine family, is a prominent factor in B cell differentiation, homeostasis, and … SLE, a chronic, multisystem … WebJan 1, 2001 · Mammalian cells transfected with BLyS cDNA secreted active protein,11,13 and overexpression of the protein in the liver of transgenic mice caused effects at distal sites such as the B-cell compartment in the secondary lymphoid organs.15 Using a BLyS-specific ELISA, we have shown that BLyS is released from cells of monocytic origin and … WebThe molecular mass of BLYS is 17 kD. Northern blot and flow cytometric analyses detected BLYS expression as a single 2.6-kb mRNA in peripheral blood mononuclear cells, spleen, lymph node, and bone marrow. Lower expression was detected in placenta, heart, lung, fetal liver, thymus, and pancreas. Surface expression of BLYS was not detected by ... eyelash serum with lash caring complex